Effects of diet and Omeprazole in patients with eosinophilic oesophagitis – a multi-centre, randomised controlled trial and investigation of novel disease mechanisms
Royal Children’s Hospital
National Health and Medical Research Council (NHMRC)
To assess whether a 4-food elimination diet (4-FED), in combination with proton pump inhibitor (PPI) treatment, is superior to PPI monotherapy in children with eosinophilic esophagitis (EoE).
After a baseline gastroscopy, patients with histologically proven EoE (≥15 eosinophils per high power field; HPF) were randomized to omeprazole 1mg/kg twice daily (max. dose 20mg b.i.d.) plus a 4-FED (cow’s milk, soy, egg, wheat) vs omeprazole monotherapy.
Children with EOE aged 0-18 years.
Recruitment completed December 2016. Data collection completed December 2016.
Study contact: [email protected]