*Recruitment Closed*

Study short name: CAKE

Study full name: Does Consumption of Baked Egg Hasten Development of Tolerance to Raw Egg in Children with Egg Allergy? - A Randomised, Controlled Trial

Principle Investigator: Maria Makrides

Administering Institute: South Australian Health & Medical Research Institute

Major funding sources: Women’s and Children’s Hospital Foundation and Australian Egg Corporation Ltd

Study focus: Treatment

Study design: Intervention

Main study aim: To help to find out if eating baked egg helps the development of tolerance to raw egg in children with allergy to raw egg.

Additional study information: Children with egg allergies were traditionally advised to avoid all forms of egg in their diet, even though they could tolerate products that contain baked egg (e.g. cake, biscuits or muffins). Research indicates that up to 70% of children with raw egg allergy can eat egg baked in a cake or muffin without apparent reaction, and this is associated with changes in the immune system that may lead to increased tolerance to egg. Children between the ages of 6 months and 5 years who could tolerate baked egg but not raw egg were enrolled into the CAKE Study. Children were randomly divided into two groups and were supplied with baked products (biscuits, muffin or bread) that either had ‘no egg’ or contained egg or for six months.

Recruitment and follow up in the CAKE Study is now complete. This CAKE 'treatment' study showed, for egg allergic children, regularly eating baked egg does not change the rate at which they develop tolerance.

Study population: Children aged 6 months – 5 years who could tolerate baked egg but not raw egg.

Study status: Recruitment completed January 2014. Data collection completed October 2014.

Where can I find more information?

Study website: https://www.sahmriresearch.org/our-research/themes/healthy-mothers-babies-children/research-list/cake

Australia New Zealand Clinical Trials Registry: https://www.australianclinicaltrials.gov.au/anzctr/trial/ACTRN12612000173897

Study contact: [email protected]

Main Publication(s):

1. Netting M, Gold M, Quinn P, El-Merhibi A, Pentilla I, Makrides M. Randomised controlled trials of a baked egg intervention in young children allergic to raw egg but not baked egg. World Allergy Organization Journal. 2017;10(1):22. doi: https://dx.doi.org/10.1186%2Fs40413-017-0152-5

Last modified: July 28th 2020