*Closed Recruitment*

Study short name: MACS

Study full name: Melbourne Atopy Cohort Study

Principle Investigator: Shyamali Dharmage

Administering Institute: University of Melbourne

Major funding source: National Health and Medical Research Council (NHMRC)

Study focus: Epidemiology

Study design: Began interventional, now observational

Main study aim: To determine the effects of early life, childhood, adolescent and early adult exposures on eczema, food allergy, asthma, hay fever and lung function.

Additional study information: The MACS study began as an intervention study examining the effects of 3 infant formulas on weaning, and now continues as an observational study.

Study population: High risk birth cohort recruited antenatally. Participants have at least 1 immediate family member (parent, sibling) with self-reported asthma/eczema/hay fever or severe food allergy.

Study status: Recruitment ongoing*, through December 2019.
*Current recruitment is following up individuals who were recruited in the 1990s and their families. This study is unable to accept volunteers who were not part of the original study cohort.

Where can I find more information?

Australia New Zealand Clinical Trials Registry: https://www.australianclinicaltrials.gov.au/anzctr/trial/ACTRN12609000734268

Study contact: [email protected]

Main Publications: MACS Publications in “Summary”

  1. Lowe AJ, Hosking CS, Bennett CM, Allen KJ, Axelrad C, Carlin JB, et al. Effect of a partially hydrolyzed whey infant formula at weaning on risk of allergic disease in high-risk children: a randomized controlled trial. Journal of Allergy & Clinical Immunology. 2011;128(2):360-365 e364. doi: https://doi.org/10.1016/j.jaci.2010.05.006.

Last modified: December 12th 2019 | Date created: April 9th 2019